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 | Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non‑alcoholic fatty liver disease
Bertot, Gustavo
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Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non‑alcoholic fatty liver disease / Bertot, Gustavo. [s.l.] : [s.n.], 2021-07-02. 10 paginas. | Registro del documento | | Título: | Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non‑alcoholic fatty liver disease | | Autor(es): | Bertot, Gustavo | | Descripción: | Fil: Bertot, Gustavo. Instituto Universitario de Ciencias de la Salud – Fundación Barceló. Secretaria de Ciencia y Tecnologia; Argentina. | | Resumen: | The immune response is critical in NAFLD pathogenesis, but the liver infiltrate’s composition and the role of each T cell population is still up for debate. To characterize liver pathogenesis in pediatric and adult cases, frequency and localization of immune cell populations [Cytotoxic T Lymphocytes (CD8+), T helper Lymphocytes (CD4+), Regulatory T lymphocytes (Foxp3+) and Th17 (IL-17A+)] were evaluated. In portal/periportal (P/P) tracts, both age groups displayed a similar proportion of CD8+ and CD4+ lymphocytes. However, comparable Foxp3+ and IL-17A+ cell frequencies were observed in pediatric cases, meanwhile, in adults Foxp3+ was higher than IL-17A+ cells. Interestingly, IL-17A+ lymphocytes seemed to be nearly exclusive of P/P area in both age groups. In intralobular areas, both pediatric and adult cases showed CD8+ lymphocytes predominance with lower frequencies of CD4+ lymphocytes followed by Foxp3+ . Severe inflammation was associated with higher intralobular Foxp3+ lymphocytes (p = 0.026) in children, and lower P/P Foxp3+ and higher IL-17A+ lymphocytes in adults. All cases with fibrosis ≥ 2 displayed P/P low Foxp3+ and high IL-17A+ lymphocyte counts. Pediatric cases with worse steatosis showed high P/P CD4+ (p = 0.023) and intralobular CD8+ (p = 0.027) and CD4+ cells (p = 0.012). In NAFLD cases, the lymphocyte liver infiltrate composition differs between histological areas. Treg and Th17 balance seems to condition damage progression, denoting their important role in pathogenesis. | | Descriptores: | | | Contribuidores: | Cairoli, Victoria; De Matteo, Elena; Rios, Daniela; Lezama, Carol; Galoppo, Marcela; Casciato, Paola; Mullen, Eduardo; Giadans, Cecilia; Preciado, Maria Victoria; Valva, Pamela | | Fecha: | 2021-07-02 | | Formato: | application/pdf | | Extensión: | 10 paginas | | Idioma: | eng | | Lugar: | 7006477, Argentina (nation) | | Sede: | Buenos Aires | | Carrera: | MEDICINA | | Notas: | Trabajo de investigación publicado |
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