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 | Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non‑alcoholic fatty liver disease
Bertot, Gustavo
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Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non‑alcoholic fatty liver disease / Bertot, Gustavo. [s.l.] : [s.n.], 2021-07-02. 10 paginas. | Registro del documento | | Título: | Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non‑alcoholic fatty liver disease | | Autor(es): | Bertot, Gustavo | | Descripción: | Fil: Bertot, Gustavo. Instituto Universitario de Ciencias de la Salud – Fundación Barceló. Secretaria de Ciencia y Tecnologia; Argentina. | | Resumen: | The immune response is critical in NAFLD pathogenesis, but the liver infiltrate’s composition and the role of each T cell population is still up for debate. To characterize liver pathogenesis in pediatric and adult cases, frequency and localization of immune cell populations [Cytotoxic T Lymphocytes (CD8+), T helper Lymphocytes (CD4+), Regulatory T lymphocytes (Foxp3+) and Th17 (IL-17A+)] were evaluated. In portal/periportal (P/P) tracts, both age groups displayed a similar proportion of CD8+ and CD4+ lymphocytes. However, comparable Foxp3+ and IL-17A+ cell frequencies were observed in pediatric cases, meanwhile, in adults Foxp3+ was higher than IL-17A+ cells. Interestingly, IL-17A+ lymphocytes seemed to be nearly exclusive of P/P area in both age groups. In intralobular areas, both pediatric and adult cases showed CD8+ lymphocytes predominance with lower frequencies of CD4+ lymphocytes followed by Foxp3+ . Severe inflammation was associated with higher intralobular Foxp3+ lymphocytes (p = 0.026) in children, and lower P/P Foxp3+ and higher IL-17A+ lymphocytes in adults. All cases with fibrosis ≥ 2 displayed P/P low Foxp3+ and high IL-17A+ lymphocyte counts. Pediatric cases with worse steatosis showed high P/P CD4+ (p = 0.023) and intralobular CD8+ (p = 0.027) and CD4+ cells (p = 0.012). In NAFLD cases, the lymphocyte liver infiltrate composition differs between histological areas. Treg and Th17 balance seems to condition damage progression, denoting their important role in pathogenesis. | | Descriptores: | | | Contribuidores: | Cairoli, Victoria; De Matteo, Elena; Rios, Daniela; Lezama, Carol; Galoppo, Marcela; Casciato, Paola; Mullen, Eduardo; Giadans, Cecilia; Preciado, Maria Victoria; Valva, Pamela | | Fecha: | 2021-07-02 | | Formato: | application/pdf | | Extensión: | 10 paginas | | Idioma: | eng | | Lugar: | 7006477, Argentina (nation) | | Sede: | Buenos Aires | | Carrera: | MEDICINA | | Notas: | Trabajo de investigación publicado |
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| | Nonalcoholic fatty liver disease: biomarkers as diagnostic tools for liver damage assessment in adult patients from Argentina
Bertot, Gustavo
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Nonalcoholic fatty liver disease: biomarkers as diagnostic tools for liver damage assessment in adult patients from Argentina / Bertot, Gustavo. [s.l.] : [s.n.], 2020-02-27. 8 paginas. | Registro del documento | | Título: | Nonalcoholic fatty liver disease: biomarkers as diagnostic tools for liver damage assessment in adult patients from Argentina | | Autor(es): | Bertot, Gustavo | | Descripción: | Fil: Bertot, Gustavo. Instituto Universitario de Ciencias de la Salud – Fundación Barceló. Secretaria de Ciencia y Tecnologia; Argentina. | | Resumen: | Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has been increasing constantly and linked to the global obesity epidemic. The NAFLD histologic spectrum ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis and hepatocellular carcinoma. Liver biopsy is the only reliable means to diagnose and stage NASH, but its invasive nature limits its use. Therefore, the prediction of hepatic injury by means of the development of new noninvasive tests represents a growing medical need. Our aim was to evaluate matrix deposition and cell-death markers, which correlate with liver injury in an NAFLD patient cohort. | | Descriptores: | | | Fecha: | 2020-02-27 | | Formato: | application/pdf | | Extensión: | 8 paginas | | Idioma: | eng | | Lugar: | 7006287, Buenos Aires (inhabited place) | | Sede: | Buenos Aires | | Carrera: | MEDICINA | | Notas: | Trabajo de investigación publicado |
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